TRADE NAMEAptor, ascardia, aspilet, aspirin, aspitrom, astika, bodrexin, cardio aspirin, farmasal, miniaspi, naspro, restor, thrombo aspilet
-GROUP
| Group | Preparations | Indication | |
| Anti-inflammatory drugs non-steroidal and non-opioid | Tablet 100-500 mg Supositoria: 50-150 mg | Analgesics (pain relievers) mild to moderate pain and antipyretic (fever) | |
| Tablet 300-500 mg | Acute migraine attack | ||
| antithrombotic | Tablet 100 mg | Low-dose aspirin to prevent platelet aggregation (prevention of cerebrovascular disease or heart attack) |
-INDICATIONS
Mild to moderate pain, including menstrual pain, headache; pain and inflammation in rheumatic diseases and bone and muscle disorders (including arthritis juvenilis); fever attack of acute migrants; anti-clotting (antiplatelet)
-CONTRAINDIKATIONS
Hypersensitivity (including asthma, angioedema, urticaria or rhinitis) to acetylsalicylic acid or NSAIDs (non steroidal anti-inflammatory drugs) other; children and adolescents under 16 years (Reye syndrome); active peptic ulcer or previous history; hemophilia and other bleeding disorders; not treatment for uric acid
Attention: Asthma, allergic disease; renal impairment; liver disorders; pregnancy and lactation; elderly; G6PD deficiency; dehydration
Pregnancy: 3rd Trimester: disrupt platelet function and the risk of bleeding; slowdown beginning perlasilan labor and increased duration and increased blood loss; avoid analgesic doses if possible in the last few weeks (low dose may be harmless); with high doses, closure of fetal ductus arteriosus and persistent pulmonary hypertension may neonates; kericterus jaundice in infants
Breast-feeding: avoid - possible risk of Reye's syndrome; regular use of high doses may affect platelet function and cause hipoprotrombinemia in infants if the reserves of vitamin K neonates less
-DOSE
Mild pain samapai moderate fever, by mouth with or after food, ADULT 300-900 mg every 4-6 hours if necessary; maximum 4 g daily; CHILD under 16 years not recommended
Mild to moderate pain, fever, per rectum, ADULT 600-900 mg inserted every 4 hours if necessary; maximum 3.6 g daily; CHILD under 16 years not recommended
Inflammatory arthritis, by mouth with or after food, ADULT 4-8 g in divided doses in acute conditions; up to 5.4 g daily may suffice in chronic conditions
Juvenilis arthritis, by mouth with or after meals, CHILD up to 130 mg / kg daily in 5-6 divided doses in acute conditions; 80-100 mg / kg daily in divided doses for maintenance dose (maintenance)
Treatment of acute migraine attack, by mouth with or after meals is recommended, ADULT 300-900 mg at first attack, can be repeated every 4-6 hours if necessary, maximum 4 g daily; CHILD under 16 years not recommended
Treatment of acute migraine attacks, per rectum, ADULT 600-900 mg inserted during the first attack, can be repeated every 4 hours if necessary; maximum 3.6 g daily; CHILD under 16 years not recommended
Prevention of cerebrovascular disease or heart attack, by mouth, ADULT 75-100 mg daily
-SIDE EFFECTS
At low doses are generally mild and infrequent, but often occurs at doses for anti-inflammatory; gastrointestinal disorders, bleeding ulcers with a hidden (major bleeding can occur); or other bleeding (subkonjungtiva); hearing loss such as tinnitus (ringing in the ears), deafness ( rare), vertigo, confusion, 9angioedema hypersensitivity reactions, bronchospasm and rash), increased bleeding time; jjarang: edema, myocarditis, blood disorders (usually thrombocytopenia)
Attention: Asthma, allergic disease; renal impairment; liver disorders; pregnancy and lactation; elderly; G6PD deficiency; dehydration
Pregnancy: 3rd Trimester: disrupt platelet function and the risk of bleeding; slowdown beginning perlasilan labor and increased duration and increased blood loss; avoid analgesic doses if possible in the last few weeks (low dose may be harmless); with high doses, closure of fetal ductus arteriosus and persistent pulmonary hypertension may neonates; kericterus jaundice in infants
Breast-feeding: avoid - possible risk of Reye's syndrome; regular use of high doses may affect platelet function and cause hipoprotrombinemia in infants if the reserves of vitamin K neonates less
-DOSE
Mild pain samapai moderate fever, by mouth with or after food, ADULT 300-900 mg every 4-6 hours if necessary; maximum 4 g daily; CHILD under 16 years not recommended
Mild to moderate pain, fever, per rectum, ADULT 600-900 mg inserted every 4 hours if necessary; maximum 3.6 g daily; CHILD under 16 years not recommended
Inflammatory arthritis, by mouth with or after food, ADULT 4-8 g in divided doses in acute conditions; up to 5.4 g daily may suffice in chronic conditions
Juvenilis arthritis, by mouth with or after meals, CHILD up to 130 mg / kg daily in 5-6 divided doses in acute conditions; 80-100 mg / kg daily in divided doses for maintenance dose (maintenance)
Treatment of acute migraine attack, by mouth with or after meals is recommended, ADULT 300-900 mg at first attack, can be repeated every 4-6 hours if necessary, maximum 4 g daily; CHILD under 16 years not recommended
Treatment of acute migraine attacks, per rectum, ADULT 600-900 mg inserted during the first attack, can be repeated every 4 hours if necessary; maximum 3.6 g daily; CHILD under 16 years not recommended
Prevention of cerebrovascular disease or heart attack, by mouth, ADULT 75-100 mg daily
-SIDE EFFECTS
At low doses are generally mild and infrequent, but often occurs at doses for anti-inflammatory; gastrointestinal disorders, bleeding ulcers with a hidden (major bleeding can occur); or other bleeding (subkonjungtiva); hearing loss such as tinnitus (ringing in the ears), deafness ( rare), vertigo, confusion, 9angioedema hypersensitivity reactions, bronchospasm and rash), increased bleeding time; jjarang: edema, myocarditis, blood disorders (usually thrombocytopenia)
DRUG INTERACTION
| adsorbent | Absorption of aspirin may be reduced by the kaolin |
| analgesic | Avoid concurrent use of aspirin with NSAIDs, increasing side effects; aspirn antithrombotic effects may be reduced by ibuprofen |
| antacids | expenditure increased by aspirin from the body of an alkaline urine as some antacids |
| anticoagulants | Increase the risk of bleeding when aspirin is given with koumarin or phenindione, because the effect of antithrombotic; of aspirin increase the anticoagulant effect of heparin |
| Antidepressants | increase the risk of bleeding when aspirin is given with an SSRI or venlafaxine |
| antiepileptic | Aspirin increases the effects of phenytoin and valproic |
| Cilostazol | Cilostazol factory suggested dose aspirin does not exceed 80 mg daily when given with Cilostazol |
| Clopidogrel | Increase the risk of bleeding when aspirin is given with clopidogrel |
| Kortikosteroid | Increase the risk of gastrointestinal bleeding and injury (ulceration) when aspirin is given with corticosteroids, corticosteroids also reduce levels of salicylate in the blood |
| Sitotoksik | Aspirin mengurangi pengeluaran metotreksat dari tubuh, meningkatkan risiko toksisitas; bula digunakan dalam pengobatan rheumatic maka dosis metotreksat harus dipantau. Pasien dilarang menggunakan aspirin tanpa konsultasi |
| Diuretik | Aspirin counteracts the effects of spironolactone diuresis; increase the risk of high-dose aspirin when aspirin is given with carbonate anhydrase inhibitors |
| Iloprost | Increase the risk of bleeding when aspirin is given with iloprost |
| Antagonis leukotrien | Aspirin increases in blood levels of zafirlukas |
| Metoclopramide | Enhanced rate of absorption of aspirin by metoclopramide |
| Probenesid | Aspirin counteracts the effects of probenecid |
| Sibutramin | Increase the risk of bleeding when aspirin is given with Sibutramin |
| Sulfinpyrazone | Aspirin counteracts the effects of sulfinpyrazone |
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