AMOXICILLIN

TRADE NAME

Amobiotic,  abdimox, Aclam, Amosine, Amoxil, Amoxillin, Amoxan, Arcamox, Bimoxyl, Bintamox, Broadamox, Bufamoxy, Corsamox, Danoxilin, Decamox, Dexymox, Erphamoxy, Etamox, Ethimox, Farmoxyl, Goxallin, Hiramox, Hufanoxil, Ikamoxyl, Inamox, Intermoxil, Kalmoxillin, Kamox, Kemosilin, Keniko, Kimoxil, Lactamox, Lapimox, Leomoxyl, Liskoma, Medimox, Mestamox, Mexylin, Mokbios, Moxaxil, Moxigra, Moxtid, Novax, Nufamox, Omemox, opimox, ospamox, Pehamoxil, Penmox, Pritamox, Ramoxyl, Robamox, Sammoxin, Scannoxyl, Silamox, Sirimox, Solpenox, Supramox, Wiamox, Topcillin, varmoxillin, Vibramox, Widecillin, Xepacillin, Xiltrop, Yefamox, Yusimox, Zemoxil.

INDICATIONS


Urinary tract infections, upper respiratory tract infections, bronchitis; pneumonia; otitis media, dental abscess and other oral infections: osteomyelitis; Lyme disease; endocarditis prophylaxis; post-splenectomy prophylaxis; gynecological infections; gonorrhea; Helicobacter pylori eradication; antrax


CONS INDICATION


- Hypersensitive to penicillinCaution:History of allergy; renal impairment; reddish spots on the glandular fever (glandular fever), cytomegalovirus infection; leukimis chronic lymphocytic, and the possibility of HIV infection; maintain adequate hydration at high doses (risk of crystalluria); pregnancy and lactation.


- Pregnancy and meyusui:Not known to be harmful in pregnancy; in very small amount of breast milk (trace amount)


DOSE


Infection by organisms sensitive; orally, adults and children over 10 years, 250 mg every 8 hours, can be duplicated in severe infections. Children over 10 years, 125 mg every 8 hours, doubled in severe infections doses.Severe respiratory tract infections or recurrent severe purulenta, by mouth, adult 3g every 12 hoursPneumonia, by mouth, adult 0.5 to 1 g every 8 hoursTooth abscess (short duration), by mouth, adult 3 g repeated once after 8 hoursUrinary tract infections (short duration), by mouth, adult 3 g repeated once after 10-12 hoursGenital chlamydial infection is not complicated, non-gonococcal urethritis, by mouth, 500mg every 8 hoursGonorrhea (short doses), by mouth, adult 3 g single dose (with probenecid 1 g)Otitis media, by mouth, adult 1 g every 8 hours; children 40mg/kg daily in 3 divided doses (maximum of 3 g day).


SIDE EFFECTS


nausea, vomiting, diarrhea; redness or toxic response; can be a serious reaction, discontinue treatment); hypersensitivity reactions including urticaria, angioedema, anaphylaxis, serum sickness-like reactions, hemolytic anemia, interstitial nephritis; rare: Antibiotic associated colitis; neutropenia;thrombocytopenia, coagulation disorders; central nervous system disorders including seizures related to high doses or impaired renal function.


DRUG INTERACTION

• Allupurinol : Increasing risk of rash when administered together with amoxicillinor ampicillin allupurinol
• Antibacterial : phenoxymetilpenicilin Absorption reduced by neomycin
• Anticoagulation INR can be disrupted by broad-spectrum penicillin such asampicillin, although the study failed to show interactions with coumarin orphenindione Penicillin.
• Probenecid Expenditure / penicillin excretion is reduced by probenecid (low risk)
• Estrogen may reduce the contraceptive effect of estrogen
• Spending Sulfinpirazone penicillin reduced by sulfinpirazon
• Citotoksik reduce expenditures metotrexate (increased risk of toxicity)