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Showing posts with label danger of toxic effects on drug use. Show all posts
Showing posts with label danger of toxic effects on drug use. Show all posts

Science Of Forensic Anthropology,


Science of forensic anthropology, including the relatively new science. Although at the beginning of the 19th century there were solving a murder case using the data and examination of bone parts - body parts, but the relationship between anthropology and the new police investigation occurred in the 1930's. Inter-gang killings in the 1930s, making the FBI began to investigate on the basis of physical anthropology. 

Second world war and civil war in Korea to help provide basic data about the information on which to base the identification used by anthropologists today. Starting from the assignment of identification on the dead soldiers. The soldiers who will fight to make health data (medical records) prior to deployment to the battlefield, the data includes age, height, history of previous illness and dental records, so the investigators are able to determine the identity of the soldiers and make the statistical data on the bones and skulls. 

In recent years, growing forensic anthropology examinations along with examination of the crime becomes more complex. Identification of the order and the rest of the body is decomposing more important for legal reasons or humanitarian reasons. 

Forensic anthropology is the application of physical sciences or biological anthropology in the legal process. An examination of the rest - the rest of the framework to help determine the identity of the body. This examination can be done as a first step to determine whether the remains are of human origin and can further determine the sex, approximate age, body shape, and the linkage of race. Checks can also estimate the time of death, cause of death and disease history before that time of life or injury caused injury to the bone structure. 

For example, if the order is found in the woods, then the order will be brought to the laboratory to determine whether the order is left is a framework of human, animal or inorganic material. If human, it will be an estimated age at death, race, gender and height of the body. If the order to show evidence that had been buried in a long time or a coffin, then this usually only indicates a history of burial than the time of death. 

Although the main task of anthropology is to determine the identity of the body, but the development can be also to determine opinions about the type and size of weapons used and the number of strokes contained in the victims of violence. Most anthropologists have a high ability to anthropology and has examined many of the remains of the order. Some of them also have experience in the field of police and medical, as well as in serology, toxicology, firearms and identification of injury due to equipment, crime scene investigation, handling and photographic evidence of crimes. And only a few anthropological analysis of footprints and handle the identification of species in relation to the estimated time of death is past. Forensic anthropology is always associated with forensic pathology, odontologi and murder investigation, or manner of death and postmortem interval. 

Keep in mind, although most of the adult skeleton consists of the same amount of bone (206), but no two the same order. Therefore observation of a distinctive pattern or order often show definite identification.


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VALPROATE ACID

INDICATIONS

All forms of epilepsy

CONS INDICATION

Active liver disease, history of severe liver disease in the family, pancreatitis, porphyria.
Attention: liver disorders (monitor liver function before and during the first 6 months of therapy), particularly in patients who at high risk: children <3 years, patients with metabolic disorders, degenerative disorders, brain disorders or severe seizures associated with mental retardation or multiple antiepileptic therapy . Also in patients with renal impairment, pregnancy, lactation, and SLE. Avoid breaking abruptly drug.

DOSE

Adults and children> 12 years of the initial dose of 600 mg daily in 2 divided doses, preferably after meals. Raise the dose of 200 mg a day after an interval of 3 days, maximum 2.5 g daily in divided doses. Maintenance dose 1-2 g daily (20-30 mg / kg daily).
Children> 20 kg initial dose of 20 mg / kg daily in divided doses.
Children <12 years, weight> 20 kg initial dose of 400 mg daily in divided doses, up to a range of 20-30 mg / kg per day, maximum 35 mg / kg daily.

SIDE EFFECTS

Gastrointestinal irritation, nausea, appetite and weight increased, tremor, hair loss, swelling, thrombocytopenia, platelet clumping resistance, impaired liver function and (rarely) fatal liver failure.
Immediately discontinue treatment if symptoms encountered limp, swelling, abdominal pain, vomiting, anorexia, jaundice, severe drowsiness, and lost control of seizures.

SPECIMENS:

Oral Liquid 200 mg / 5 ml, 100 mg tablets, enteric-coated tablet 200 mg and 500 mg.

INTERACTION

Name of Drug Interactions with Valproate Acid
  1. Effect of aspirin rose valproic
  2. Antibiotic levels in plasma valproate may be reduced by doripenem and ertapenem, were reduced by meropenem, and metabolism is inhibited by erythromycin
  3. Another anticonvulsant valproate in plasma levels reduced by carbamazepin, and the active metabolite carbamazepin increased.
  4. Gastrointestinal drug metabolism is inhibited by valproic simetidine


FOLIC ACID


INDICATIONS


Megaloblastic anemia, neural tube defect prevention, prophylaxis in chronic hemolytic status, prophylaxis of folate deficiency in dialysis patients.


SIDE EFFECTS


Gastrointestinal disorders (rare)
Caution: should not be given a single in pernicious anemia and other symptoms of vitamin B12 deficiency.


DOSE


Megaloblastic anemia:


- Adults and children> 1 yr: 5 mg daily for 4 months (in pregnant women, until just months). In the case of absorption disorders, can inaikkan dose to 15 mg per day; maintenance dose of 5 mg every 1-7 days.
- Children <1 yr: 500 micrograms / kg per day for 4 months; maintenance dose of 500 micrograms / kg per day every 1-7 days


Prevention of neural tube defects, administered before and during pregnancy:


- Low risk: 400 micrograms per day until 12 weeks gestation.
- High risk (family history, never have children with neural tube defects, maternal history of diabetes mellitus, sickle cell anemia in the mother): 5 mg per day up to 12 weeks of gestation.


Prophylaxis in chronic hemolytic status:


Adult, per oral, 5 mg every 1-7 days depending on the underlying disease.


Prophylaxis of folate deficiency in dialysis patients:


Adults, by mouth: 5 mg every 1-7 days
Children 1-12 years: 250 micrograms / kg (max 10 mg) 1x a day
Children 12-18 years: 5-10 mg 1x a day.


SPECIMENS


Tablets 400 micrograms, syrup 2.5 mg / 5 ml and 400 micrograms / 5 ml, injection 15 mg in 1 ml ampoule.


DRUG INTERACTION


Reduced folate absorption by sulfasalazine.
Levels of phenytoin, primidone, and phenobarbital in plasma is reduced by folic acid

The pfizer Guide To Careers in Pharmacy


We are living in the most exciting period in the history of pharmaceuticals, as new options lead to new opportunities for those of us in the field and those about to join us. Pharmacists are at a zenith in our ability to manage, cure and prevent disease. Demographics in this country practically ensure a bright future for those entering the profession. We’re witnessing a double dynamic in our population: growth in the number of births and an extended lifespan for men and women.
The record number of baby-boomers graduating into Social Security pensioners has set the stage for an increased use of drugs. When Medicare kicks in for the largest group of elderly ever seen, there will be a pronounced increase in pharmaceutical usage. It is estimated that the number of Americans over 65, now 38 million, will mushroom to 80 million in the next decade. Add to the mix the continuing discovery of new drugs and it’s easy to understand why, over the next few years, the number of prescriptions dispensed is expected to more than double.


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ASTHMA

Symptoms of Asthma


Frequency and severity of asthma attacks varies. Some people more often free of symptoms and only experience shortness of breath attacks are brief and mild,occurring at any time.
Other patients almost always have a cough and wheezing (asthma) and have a great attack after suffering a viral infection, exercise or after exposure to theallergen or irritant. Crying or laughing hard can also cause symptoms.
An asthma attack can occur suddenly marked by breath sounds (wheezing,wheezing, asthma), cough and shortness of breath. Wheezing, especiallyaudible when the patient breathed. At other times, an asthma attack occurs slowly with symptoms that gradually worsened.



bronkokonstriksi
Image: asthma due to narrowing, inflammation
& Bronchial muscle constriction.

In the second situation, which was first felt by a sufferer of asthma are shortness of breath, cough or tightness in the chest. The attack could take place within a few minutes or may last up to several hours, even for a few days.Initial symptoms in children can include itching in the chest or neck. Dry cough at night or during exercise could also be the only symptom. During asthma attacks, shortness of breath may become more severe, causing anxiety. As a reaction to anxiety, patients will also be spending a lot of sweat.In a very severe attack, the patient became difficult to speak because of crowded very great. Although he has suffered a severe attack, the patient will usually recover completely.Confusion, lethargy (decreased state of consciousness, where people like to sleep soundly, but can be aroused briefly and then immediately fall asleep again) and cyanosis (bluish skin looks) is a sign that the patient oxygen supply is very limited and needs immediate treatment.Sometimes some of the alveoli (air pockets in the lungs) can rupture and cause the air collects in the pleural cavity or cause air to accumulate around the chest organs. This will exacerbate the difficulty felt by the patient.

Diagnosis of Asthma
Diagnosis based on typical symptoms. To confirm the diagnosis can be repeated spirometry examination. Spirometry is also used to assess the severity of airway obstruction and to monitor treatment.Determining factor is often not easy to asthma triggers. Allergy skin tests can help determine the allergens that trigger asthma symptoms. If the diagnosis is doubtful or if it is felt very important to know the factors triggering the occurrence of asthma, it can be done bronchial challenge test.When you visit your doctor for a consultation, your doctor will ask about your family health history that is whether there is one member of your family who suffer from asthma?This question will support their opinions to test your lung function or breathing tests to assure their examination results before prescribing / medicines and therapies to you.Test the function of the respiratory tract / lung is used to measure your ability to breathe. Results of chest X-ray can show if there is blockage of the respiratory tract which is an indication of asthma.

sistem pernafasan

Asthma is a disease that can happen to anyone of any age and can arise, however, asthma is generally more common in children aged under five years old and adults at the age of about thirty years. Prof. Dr. Dr. Heru Sundaru, Sp.PD, KAI from the Faculty of medicine University of Indonesia said, "cases of asthma in children in Indonesia a little higher than the adult. Later asthma in children will be lost in part, and will appear again as an adult because of the way of nature ". Experts believe that asthma Asthma is a hereditary disease and most people who suffer from asthma due to allergy to a particular source of allergies (allergens). Allergens are derived from environmental factors.
Causes of Asthma
The term is actually less precise cause of asthma because until now the cause of asthma is unknown. It has been much research done by experts in the field of asthma to explain the causes of asthma, but not a single theory or hypothesis can be accepted or agreed yanga all the experts. Nevertheless a clear airway with asthma have a peculiar trait that is highly sensitive to various stimuli (bronchial airway hyperreactivity = hipereaktivitas).Smoking, mental stress, allergens in normal people but does not cause asthma in people with asthma can lead to an attack last stimulation.

respon imun
Image : The Immune Response


In people with asthma, narrowing of the airways in response to stimuli in the normal lung will not affect the respiratory tract. This narrowing can be triggered by various stimuli, such as pollen, dust, animal dander, smoke, cold air and exercise.In an asthma attack, smooth muscle spasm of the bronchi and the tissues that line the airways have swollen because of inflammation and the release of mucus into the airways.This will reduce the diameter of the airways (called bronchoconstriction) and this causes narrowing of the patient must exert every effort in order to breathe.Certain cells in the airways (particularly mast cells) allegedly responsible for the beginning of this constriction. Mast cells throughout the bronchi releasing materials such as histamine and leukotrienes that cause:smooth muscle contractionincreased mucus formationmovement of certain white blood cells into the bronchi.Mast cells release the material as a response to something they recognize as foreign (an allergen), such as pollen, fine dust contained in the home or animal fur.
But asthma can also occur in some people without a specific allergy. The same reaction occurs if the person is doing sports or being in the weather dingin.Stres and anxiety can also trigger the release of histamine and leukotrienes.Other cells (eosnofil) are found in asthmatic airways release other materials (as well as leukotrienes), which also causes constriction of the airways.
Factor Triggers Asthma AttacksThe trigger resulted in disruption of the respiratory tract and cause constriction of the airways (bronchoconstriction). Triggers do not cause inflammation. Many of the medical community consider the trigger and bronchoconstriction are acute respiratory disorders, which does not mean asthma.
The symptoms and bronchoconstriction induced by triggers occur instantaneously, takes place in a short time and is more easily overcome in a short time. But the respiratory tract will react more quickly when an existing or inflammation occurs.Factor in patientsGenetic AspectsPossible allergiesAirways that are easily arousedGenderRace / ethnicityEnvironmental factorsThe materials in the room:House dust mitesAnimals, cockroachesThe materials in the outdoors:Flower pollenMushroomsCertain foods, preservatives, flavoring, food coloringCertain drugsIrritants (perfumes, odors stimulate, household spray)Excessive emotional expressionCigarette smoke from active smokers and passiveAir pollution from outdoor and indoorRespiratory tract infectionsExercise induced asthma, those with asthma relapse when doing certain physical activitiesChanges in weather
attention

Treatment Of Asthma 

The goal of treatment is to free anti-asthma sufferer of asthma attacks. This can be achieved by treating the asthma attack is happening or prevent asthma attacks from happening.Treat here is not meant to cure the illness, but eliminate the symptoms of tightness, coughing, or wheezing. Circumstances that have been free of symptoms of asthma was further maintained that the attacks of asthma do not come back.Drugs can make people with asthma live a normal life. Immediate treatment to control asthma attacks differ from routine treatment to prevent asthma attacks.To treat asthma attack that is happening is needed cure asthma symptoms immediately. The drug consists of classes bronchodilators and systemic corticosteroids group.Mean bronchodilator drugs that can dilate the airways by relaxing muscles in the airways that are shriveled, whereas corticosteroids are anti-inflammatory and allergy medications that are given with the aim of which is transmitted systemically throughout the body via blood circulation.
There is a group of people who are so often under attack so that almost never experienced a period free of symptoms of asthma. This is called chronic circumstances that can last for months and even years. 
Treatment requires long periods of time and the patient must take medication every day.
Beta-2 agonists adrenergic receptorsIs the best medicine to reduce asthma attacks that occur suddenly and to prevent attacks that may be triggered by exercise. Bronchodilators stimulated by widening the airway beta-adrenergic receptors.

Bronchodilators that work on all beta-2 adrenergic receptors (eg adrenaline), causing side effects such as rapid heartbeat, restlessness, headaches and tremors (shaking) of muscle.Bronchodilators are only working on the beta-2 adrenergic receptors (which are mainly found in cells in the lungs), has few side effects on other organs.Bronchodilators (eg albuterol), causes fewer side effects compared with bronchodilators that work on all beta-2 adrenergic receptors.Most bronchodilators work within a few minutes, but the effect only lasts for 4-6 hours. Newer bronchodilators have a longer effect, but because it works more slowly, then the drug is more widely used to prevent attacks.
Bronchodilators are available in the form of tablets, injections or inhalers (inhaled drugs) and very effective. Bronchodilator inhalation drugs will precipitate directly into the airways, so initially it works fast, but can not reach the airway becomes blocked by weight.
Bronchodilators by mouth (swallowed) and injections can reach the area, but has side effects and the early works tend to be slower. Another type of bronchodilator theophylline. Theophylline is usually given by mouth (swallowed); available in various forms, from tablets and syrup until the capsule short-acting and long-acting tablet.In a severe asthma attack, can be given intravenously (through a vein). The amount of 

theophylline in the blood can be measured in the laboratory and should be monitored closely, because the amount is too small will have no effect, while the amount is too much can cause abnormal heart rhythms or seizures.At the time of first taking theophylline, the patient may feel a bit queasy or uneasy. Both of these side effects usually disappear when the body can adjust to the medication.In larger doses, the patient may feel a rapid heartbeat or palpitations (heart pounding). Can also occur insomnia (difficulty sleeping), agitation (anxiety, phobia), vomiting, and seizures.
CorticosteroidsCorticosteroids block the inflammatory response and is very effective in reducing symptoms of asthma. If used long term, gradually corticosteroids will cause a reduction in the likelihood of an attack of asthma by reducing airway sensitivity to some stimuli.But the use of corticosteroid tablets or injections of the long term can cause:impaired wound healing processimpaired growth of childrencalcium loss from bonesgastric bleedingPremature cataractselevated levels of blood sugarweight gainhungermental disordersTablets or injections of corticosteroids can be used for 1-2 weeks to reduce severe asthma attacks. Corticosteroids by mouth (swallowed) are given for long term only if other treatments do not control asthma symptoms.For long-term use of corticosteroid inhalers are usually given because the inhalers, a drug that reached the lungs 50 times more than the drugs to other body parts.
Cromolin and NedocromilBoth drugs are thought to block the release of inflammation from mast cells and cause a reduction in the possibility of shrinkage of the airways. This medicine is used to prevent attacks, not to treat an attack.These drugs are especially effective for children and for asthma because of sports. This drug is very safe, but relatively expensive and must be taken regularly even though the patient free of symptoms.
Anticholinergic drugsThis drug works by blocking the smooth muscle contraction and the formation of excessive mucus in the bronchi by acetylcholine. Furthermore, this drug will cause a widening of the airways in patients who previously had consumed beta2-adrenergic receptor agonists. Examples of these drugs are atropine and ipratropium bromide.
Leukotriene modifiersIs a new drug to help control asthma. These drugs prevent the action or formation of leukotrienes (chemicals made by the body that cause symptoms of asthma). For example montelucas, zafirlucas and zileuton.

Treatment For Acute Asthma Attacks

An attack of asthma should get treatment as soon as possible to open the airways. Drugs used to prevent also used to treat asthma, but in higher dosesor in a different form.
Beta-2 agonists adrenergic receptor used in the form of inhalers (inhaled medications) or as a nebulizer (for shortness of breath very heavy). Nebulizerdirects air or oxygen under pressure through a solution of the drug, resulting in amist to be inhaled by the patient.
Treatment of asthma can also be done by giving injections of epinephrine or terbutaline under the skin and aminophylline (theophylline similar) viaintravenous infusion.
Patients who experience a great attack and showed no improvement on othertreatment, can get a corticosteroid injection, usually intravenously (through a vein). In a severe asthma attack is usually a low blood oxygen levels, so given extraoxygen. In case of dehydration, may need to be given fluids intravenously. If asuspected infection, given antibiotics. During a severe asthma attack, carried out:
examination of oxygen and carbon dioxide levels in the blood
lung function tests (usually with a spirometer or peak flow meter)
chest X-ray examination
Long-Term Asthma Treatment
One of the treatment of asthma is the most effective agonist inhalers containingbeta-2 adrenergic receptor. Excessive use of inhalers can cause heart rhythmdisturbances.
If you use a bronchodilator inhaler 2-4 times / day for 1 month is not able to reduce symptoms, can be added inhaler corticosteroids, leukotriene modifierscromolin or. If symptoms persist, especially at night, can also be addedtheophylline by mouth.


Pouchers Perfumes Cosmetics And Soaps 10th Edition




Table of sContributors. Preface. Foreword. Part 1: Historical Background. 1. W.A. Poucher's Influence on the Early 20th Century Cosmetic Industry; H. Butler. 2. Cosmetics through the Ages; H. Butler. Part 2: Cosmetics For Everyday Use. 3. Antiperspirants and Deodorants; P. Klepak, J. Walkey. 4. Bath and Shower Products; A.L.L. Hunting. 5. Colouring Materials Used in Decorative Cosmetics and Colour Matching; P. Riley. 6. Decorative Cosmetics; P. Riley. 7. Dental Hygiene; S. Mason, S. Hodgetts. 8. Hair Treatments; F.J. Mottram, C.E. Lees. 9. Hair Shampoos; F.J. Mottram, C.E. Lees. 10. Haircolourants; B.P. Murphy. 11. Manicure Preparations; M.L. Schlossman. 12. Men's Toiletries; P. Paniccia. 13. Pressurized Dispensers; J. McAllister. 14. Skin Preparations; G. Abamba. 15. Soap; M.J. Willcox. 16. Sun Damage and Sunscreen Preparations; M. Brown, N. Fardell. Part 3: Stability and Safety. 17. Analytical Methods; K. Spears. 18. Efficacy Testing of Cosmetics and Toiletries; M. Roberts. 19. Emulsion Theory; J.L. Knowlton. 20. Legislation and Safety Regulations for Cosmetics in the United States, the European Union and Japan; P.D. Wilkes. 21. Microbiological Control of Cosmetics; H. Butler. 22. Safety; J.D. Middleton. 23. Stability; J.S. Cannell. Part 4: Perfumes: Their Manufacture in Products and Psychology in Use. 24. Perfume and the Manufacture of Consumer Products; N.J. Van Abbé. 25. The Psychology of Fragrance and


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ANTACIDS

TRADE NAME

Aludrox, Distracid, Gevisco, Gelusil, Locid, Maaloxan, Masigel, Palliacol, Posphalugel, Rennie, Riopan, Solugastril,and Talcid 

A. Aluminum Hydroxide


INDICATIONS


Overcome the symptoms of dyspepsia (ulcer and ulcer don), gastro-esophageal reflux disease, hyperphosphatemia.

CONS INDICATION

Hipofosfatemia, gastrointestinal bleeding who have not been diagnosed, appendicitis. Not safe for infants and neonates.

DOSE

adults: 1-2 tablets chewed 4 times daily and at bedtime or 5-10 ml suspension 4 times daily between meals and before bed children 6-12 years: 5 ml, maximum 3 times a day.
Caution: Do not take other medicines within 2-4 hours after taking this medicine. Can be drunk with water to reduce constipation.

SIDE EFFECTS

Constipation, use in large doses can cause intestinal blockage, hipofosfatemia, hipercalciuria, increased risk of osteomalacia, dementia, microcytic anemia in patients with renal failure.

SPECIMENS

Oral liquid: 320 mg / 5 ml
Tablets: 500 mg.

B. Magnesium Hydroxide

INDICATIONS

Overcome the symptoms of dyspepsia (ulcer and ulcer don), gastro-esophageal reflux disease.

CONS INDICATION

Severe kidney damage

DOSE

Adults: 5-10 ml, repeated according to patient needs.

SIDE EFFECTS

Diarrhea, hipermagnesemia thus reducing tendon reflexes and respiratory depression, nausea, vomiting, reddening of the skin, thirst, hypotension, drowsiness, muscle weakness, weak pulse, coma, and cardiac arrest (in the severe renal abnormalities).

SPECIMENS

Oral fluid, equivalent to 550 mg of magnesium oksida/10 ml.

C. COMBINATION OF ALUMINUM AND MAGNESIUM (ACITRAL, antacids doen)

INDICATIONS

Dyspepsia, GERD

CONS INDICATION

Hipofosfatemia, gastrointestinal bleeding who have not been diagnosed, appendicitis, severe kidney damage. Not safe for infants and neonates.

DOSE

Adults: 1-2 tablets chewed 4 times daily and at bedtime or 5-10 ml suspension 4 times daily between meals and before bed
Children 6-12 years: 5 ml, meals and before bed

SIDE EFFECTS

The combination of aluminum and magnesium to reduce gastrointestinal side effects compared with separate preparations (see above).

SPECIMENS

Tablet: Aluminum Hydroxide 200 mg, Magnesium Hydroxide 200 mg.
Suspension: per 5 ml contains 200 mg Aluminum Hydroxide, Magnesium Hydroxide 200 mg

AMOXICILLIN

TRADE NAME


Amobiotic,  abdimox, Aclam, Amosine, Amoxil, Amoxillin, Amoxan, Arcamox, Bimoxyl, Bintamox, Broadamox, Bufamoxy, Corsamox, Danoxilin, Decamox, Dexymox, Erphamoxy, Etamox, Ethimox, Farmoxyl, Goxallin, Hiramox, Hufanoxil, Ikamoxyl, Inamox, Intermoxil, Kalmoxillin, Kamox, Kemosilin, Keniko, Kimoxil, Lactamox, Lapimox, Leomoxyl, Liskoma, Medimox, Mestamox, Mexylin, Mokbios, Moxaxil, Moxigra, Moxtid, Novax, Nufamox, Omemox, opimox, ospamox, Pehamoxil, Penmox, Pritamox, Ramoxyl, Robamox, Sammoxin, Scannoxyl, Silamox, Sirimox, Solpenox, Supramox, Wiamox, Topcillin, varmoxillin, Vibramox, Widecillin, Xepacillin, Xiltrop, Yefamox, Yusimox, Zemoxil.
INDICATIONS


Urinary tract infections, upper respiratory tract infections, bronchitis; pneumonia; otitis media, dental abscess and other oral infections: osteomyelitis; Lyme disease; endocarditis prophylaxis; post-splenectomy prophylaxis; gynecological infections; gonorrhea; Helicobacter pylori eradication; antrax


CONS INDICATION


- Hypersensitive to penicillinCaution:History of allergy; renal impairment; reddish spots on the glandular fever (glandular fever), cytomegalovirus infection; leukimis chronic lymphocytic, and the possibility of HIV infection; maintain adequate hydration at high doses (risk of crystalluria); pregnancy and lactation.


- Pregnancy and meyusui:Not known to be harmful in pregnancy; in very small amount of breast milk (trace amount)


DOSE


Infection by organisms sensitive; orally, adults and children over 10 years, 250 mg every 8 hours, can be duplicated in severe infections. Children over 10 years, 125 mg every 8 hours, doubled in severe infections doses.Severe respiratory tract infections or recurrent severe purulenta, by mouth, adult 3g every 12 hoursPneumonia, by mouth, adult 0.5 to 1 g every 8 hoursTooth abscess (short duration), by mouth, adult 3 g repeated once after 8 hoursUrinary tract infections (short duration), by mouth, adult 3 g repeated once after 10-12 hoursGenital chlamydial infection is not complicated, non-gonococcal urethritis, by mouth, 500mg every 8 hoursGonorrhea (short doses), by mouth, adult 3 g single dose (with probenecid 1 g)Otitis media, by mouth, adult 1 g every 8 hours; children 40mg/kg daily in 3 divided doses (maximum of 3 g day).


SIDE EFFECTS


nausea, vomiting, diarrhea; redness or toxic response; can be a serious reaction, discontinue treatment); hypersensitivity reactions including urticaria, angioedema, anaphylaxis, serum sickness-like reactions, hemolytic anemia, interstitial nephritis; rare: Antibiotic associated colitis; neutropenia;thrombocytopenia, coagulation disorders; central nervous system disorders including seizures related to high doses or impaired renal function.


DRUG INTERACTION



  • Allupurinol : Increasing risk of rash when administered together with amoxicillinor ampicillin allupurinol
  • Antibacterial : phenoxymetilpenicilin Absorption reduced by neomycin
  • Anticoagulation INR can be disrupted by broad-spectrum penicillin such asampicillin, although the study failed to show interactions with coumarin orphenindione Penicillin.
  • Probenecid Expenditure / penicillin excretion is reduced by probenecid (low risk)
  • Estrogen may reduce the contraceptive effect of estrogen
  • Spending Sulfinpirazone penicillin reduced by sulfinpirazon
  • Citotoksik reduce expenditures metotrexate (increased risk of toxicity)



Pathology and therapeutics for Pharmacist

C L I N I C A L P H A R M A C Y has  been    defined   in  many different ways, according to the interests and outlook of the practitioner. We take a very broad definition, encompassing all aspects of the use of medicines in patients and of responding  patients’ concerns about their health. It is thus an    essential component of the practice of virtually all pharmacists, whether working in the comunnity, in hospital or in industry, and must be based on a sound knowledge of the mechanisms of disease and the principles of drug selection. It has been  a  principle  of  our  teaching  that  clinical pharmacy practice requires an understanding of the medical process and of the nature of serious diseases and their treatment. This must underlieany involvement of pharmacists in contributing to the management of patients, or in the diagnosis and management of minor illness. Since pharmacists have to work with clinicians, and there are  well   established   intellectual   disciplines   in medicine for diagnosis and management, aspiring clinical pharmacists need to understand the way in which doctors approach the diagnosis of disease and the treatment of patients







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