Rheumatoid Arthritis, Current Dirrections in Autoimmune

During the last decades, investigation into rheumatoid arthritis has benefited from the enormous growth in understanding principal functions of the immune system and the explosion in the knowledge of molecules involved in regulating normal and pathologic immune responses. Despite this progress, the disease has defied a unifying concept and new challenges and perspectives have emerged. Once again, it is becoming evident that research of autoimmune diseases is not a one-way street but a dialectic process between basic science and disease studies. We have learned that rheumatoid arthritis is not a single mechanism-single molecule-single gene disease. The chapters commissioned in this volume illustrate the many facets of disease pathogenesis.

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